Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

Bradley T. Lang, Jared M. Cregg, Marc A. DePaul, Amanda P. Tran, Kui Xu, Scott M. Dyck, Kathryn M. Madalena, Benjamin P. Brown, Yi-Lan Weng, Shuxin Li, Soheila Karimi-Abdolrezaee, Sarah A. Busch, Yingjie Shen and Jerry Silver ()
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Bradley T. Lang: Case Western Reserve University School of Medicine
Jared M. Cregg: Case Western Reserve University School of Medicine
Marc A. DePaul: Case Western Reserve University School of Medicine
Amanda P. Tran: Case Western Reserve University School of Medicine
Kui Xu: Center for Brain and Spinal Cord Repair, Wexner Medical Center at The Ohio State University
Scott M. Dyck: University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada
Kathryn M. Madalena: Case Western Reserve University School of Medicine
Benjamin P. Brown: Baldwin Wallace University
Yi-Lan Weng: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Shuxin Li: Shriners Hospital’s Pediatric Research Center (Center for Neural Repair and Rehabilitation), Temple University School of Medicine
Soheila Karimi-Abdolrezaee: University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada
Sarah A. Busch: Case Western Reserve University School of Medicine
Yingjie Shen: Center for Brain and Spinal Cord Repair, Wexner Medical Center at The Ohio State University
Jerry Silver: Case Western Reserve University School of Medicine

Nature, 2015, vol. 518, issue 7539, 404-408

Abstract: Regeneration and plasticity after spinal cord injury are limited by inhibitory proteoglycans; here, modulation of a receptor for proteoglycans in rats is shown to lead to functional recovery after injury.

Date: 2015
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DOI: 10.1038/nature13974

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