Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

Bryce W. Carey, Lydia W. S. Finley, Justin R. Cross, C. David Allis () and Craig B. Thompson ()
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Bryce W. Carey: Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University
Lydia W. S. Finley: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Justin R. Cross: Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center
C. David Allis: Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University
Craig B. Thompson: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center

Nature, 2015, vol. 518, issue 7539, 413-416

Abstract: If deprived of exogenous glutamine, naive mouse embryonic stem cells are shown to be capable of generating the amino acid from other sources to enable their proliferation; the stem cells use glutamine and glucose catabolism to maintain a high level of intracellular α-ketoglutarate and promote demethylation of chromatin and ensure sufficient expression of pluripotency-associated genes.

Date: 2015
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DOI: 10.1038/nature13981

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