Cell-of-origin chromatin organization shapes the mutational landscape of cancer

Paz Polak, Rosa Karlić, Amnon Koren, Robert Thurman, Richard Sandstrom, Michael S. Lawrence, Alex Reynolds, Eric Rynes, Kristian Vlahoviček, John A. Stamatoyannopoulos () and Shamil R. Sunyaev ()
Additional contact information
Paz Polak: Brigham & Women’s Hospital and Harvard Medical School
Rosa Karlić: Bioinformatics Group, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia
Amnon Koren: The Broad Institute of MIT and Harvard
Robert Thurman: University of Washington
Richard Sandstrom: University of Washington
Michael S. Lawrence: The Broad Institute of MIT and Harvard
Alex Reynolds: University of Washington
Eric Rynes: University of Washington
Kristian Vlahoviček: Bioinformatics Group, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia
John A. Stamatoyannopoulos: University of Washington
Shamil R. Sunyaev: Brigham & Women’s Hospital and Harvard Medical School

Nature, 2015, vol. 518, issue 7539, 360-364

Abstract: An analysis of cell-type-specific epigenomic features reveals a relationship between epigenomic and mutational profiles; chromatin characteristics can explain a large proportion of mutational variance in cancer genomes and the mutational distribution can identify the probable cell type from which a given cancer originated from.

Date: 2015
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DOI: 10.1038/nature14221

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