Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

Terrence N. Wong, Giridharan Ramsingh, Andrew L. Young, Christopher A. Miller, Waseem Touma, John S. Welch, Tamara L. Lamprecht, Dong Shen, Jasreet Hundal, Robert S. Fulton, Sharon Heath, Jack D. Baty, Jeffery M. Klco, Li Ding, Elaine R. Mardis, Peter Westervelt, John F. DiPersio, Matthew J. Walter, Timothy A. Graubert, Timothy J. Ley, Todd E. Druley, Daniel C. Link () and Richard K. Wilson
Additional contact information
Terrence N. Wong: Washington University
Giridharan Ramsingh: University of Southern California
Andrew L. Young: Washington University
Christopher A. Miller: The Genome Institute, Washington University
Waseem Touma: Washington University
John S. Welch: Washington University
Tamara L. Lamprecht: Washington University
Dong Shen: AstraZeneca
Jasreet Hundal: The Genome Institute, Washington University
Robert S. Fulton: The Genome Institute, Washington University
Sharon Heath: Washington University
Jack D. Baty: Washington University
Jeffery M. Klco: Washington University
Li Ding: Washington University
Elaine R. Mardis: The Genome Institute, Washington University
Peter Westervelt: Washington University
John F. DiPersio: Washington University
Matthew J. Walter: Washington University
Timothy A. Graubert: Washington University
Timothy J. Ley: Washington University
Todd E. Druley: Washington University
Daniel C. Link: Washington University
Richard K. Wilson: The Genome Institute, Washington University

Nature, 2015, vol. 518, issue 7540, 552-555

Abstract: Somatic TP53 mutations are highly prevalent in therapy-related acute myeloid leukaemia and myelodysplastic syndrome, which arise as complications of cytotoxic chemotherapy or radiotherapy; although it was believed that these TP53 mutations are directly induced by cytotoxic therapy, new data indicate that they predate cytotoxic therapy and that haematopoietic progenitors harbouring these pre-existing mutations may selectively expand after exposure to chemotherapy or radiotherapy.

Date: 2015
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DOI: 10.1038/nature13968

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