Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Elisa Gomez Perdiguero, Kay Klapproth, Christian Schulz, Katrin Busch, Emanuele Azzoni, Lucile Crozet, Hannah Garner, Celine Trouillet, Marella F. de Bruijn, Frederic Geissmann () and Hans-Reimer Rodewald
Additional contact information
Elisa Gomez Perdiguero: Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK
Kay Klapproth: German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany
Christian Schulz: Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK
Katrin Busch: German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany
Emanuele Azzoni: MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital University of Oxford, Oxford OX3 9DS, UK
Lucile Crozet: Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK
Hannah Garner: Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK
Celine Trouillet: Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK
Marella F. de Bruijn: MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital University of Oxford, Oxford OX3 9DS, UK
Frederic Geissmann: Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London SE1 1UL, UK
Hans-Reimer Rodewald: German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany

Nature, 2015, vol. 518, issue 7540, 547-551

Abstract: To determine the origin of adult tissue-resident macrophages, a mouse lineage tracing study has revealed that these cells derive from erythro-myeloid progenitors in the yolk sac that are distinct from fetal and adult haematopoietic stem cells.

Date: 2015
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DOI: 10.1038/nature13989

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