Enhancer–core-promoter specificity separates developmental and housekeeping gene regulation

Muhammad A. Zabidi, Cosmas D. Arnold, Katharina Schernhuber, Michaela Pagani, Martina Rath, Olga Frank and Alexander Stark ()
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Muhammad A. Zabidi: Research Institute of Molecular Pathology IMP, Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Cosmas D. Arnold: Research Institute of Molecular Pathology IMP, Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Katharina Schernhuber: Research Institute of Molecular Pathology IMP, Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Michaela Pagani: Research Institute of Molecular Pathology IMP, Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Martina Rath: Research Institute of Molecular Pathology IMP, Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Olga Frank: Research Institute of Molecular Pathology IMP, Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria
Alexander Stark: Research Institute of Molecular Pathology IMP, Vienna Biocenter VBC, Dr Bohr-Gasse 7, 1030 Vienna, Austria

Nature, 2015, vol. 518, issue 7540, 556-559

Abstract: The core promoters of developmental and housekeeping genes are shown to have distinct specificities for different enhancer sequences in Drosophila, and this specificity separates developmental and housekeeping gene regulatory programs across the genome.

Date: 2015
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DOI: 10.1038/nature13994

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