N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

Nian Liu, Qing Dai, Guanqun Zheng, Chuan He, Marc Parisien () and Tao Pan ()
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Nian Liu: The University of Chicago
Qing Dai: The University of Chicago
Guanqun Zheng: The University of Chicago
Chuan He: The University of Chicago
Marc Parisien: The University of Chicago
Tao Pan: The University of Chicago

Nature, 2015, vol. 518, issue 7540, 560-564

Abstract: The binding motifs for many RNA-binding proteins are normally buried within structured regions; now, the N6-methyladenosine modification is shown to act as a switch to remodel these regions, expose the motif, and thereby facilitate binding of RNA-binding proteins.

Date: 2015
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DOI: 10.1038/nature14234

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