Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation

Valerie Garcia (), Stephen Gray, Rachal M. Allison, Tim J. Cooper and Matthew J. Neale ()
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Valerie Garcia: Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK
Stephen Gray: Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK
Rachal M. Allison: Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK
Tim J. Cooper: Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK
Matthew J. Neale: Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK

Nature, 2015, vol. 520, issue 7545, 114-118

Abstract: Meiotic recombination is initiated by a fairly uniform distribution of hundreds of DNA double-strand breaks catalysed by the Spo11 protein; here, Tel1 (orthologue of human ATM) is shown to be required for the localized inhibition that prevents double-strand breaks from forming close to one another.

Date: 2015
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DOI: 10.1038/nature13993

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