G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

Masoud Ghamari-Langroudi (), Gregory J. Digby, Julien A. Sebag, Glenn L. Millhauser, Rafael Palomino, Robert Matthews, Taneisha Gillyard, Brandon L. Panaro, Iain R. Tough, Helen M. Cox, Jerod S. Denton and Roger D. Cone ()
Additional contact information
Masoud Ghamari-Langroudi: Vanderbilt University Medical Center
Gregory J. Digby: Vanderbilt University Medical Center
Julien A. Sebag: Vanderbilt University Medical Center
Glenn L. Millhauser: University of California
Rafael Palomino: University of California
Robert Matthews: Vanderbilt University Medical Center
Taneisha Gillyard: Vanderbilt University Medical Center
Brandon L. Panaro: Vanderbilt University Medical Center
Iain R. Tough: King’s College London, Wolfson Centre for Age-Related Diseases, Guy’s Campus, London SE1 1UL, UK
Helen M. Cox: King’s College London, Wolfson Centre for Age-Related Diseases, Guy’s Campus, London SE1 1UL, UK
Jerod S. Denton: Vanderbilt University Medical Center
Roger D. Cone: Vanderbilt University Medical Center

Nature, 2015, vol. 520, issue 7545, 94-98

Abstract: α-MSH and AgRP, two hypothalamus-derived peptides with opposing actions on the melanocortin-4 receptor (MC4R), modulate neurons driving feeding behaviour; although previous downstream mechanisms of cellular modulation by these peptides have been determined, here α-MSH and AgRP are shown to regulate neural activity by coupling MC4R to Kir7.1 potassium channels and closing or opening them, respectively.

Date: 2015
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DOI: 10.1038/nature14051

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