Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

Shruti Naik, Nicolas Bouladoux, Jonathan L. Linehan, Seong-Ji Han, Oliver J. Harrison, Christoph Wilhelm, Sean Conlan, Sarah Himmelfarb, Allyson L. Byrd, Clayton Deming, Mariam Quinones, Jason M. Brenchley, Heidi H. Kong, Roxanne Tussiwand, Kenneth M. Murphy, Miriam Merad, Julia A. Segre and Yasmine Belkaid ()
Additional contact information
Shruti Naik: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Nicolas Bouladoux: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Jonathan L. Linehan: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Seong-Ji Han: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Oliver J. Harrison: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Christoph Wilhelm: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Sean Conlan: Translational and Functional Genomics Branch, National Human Genome Research Institute
Sarah Himmelfarb: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Allyson L. Byrd: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Clayton Deming: Translational and Functional Genomics Branch, National Human Genome Research Institute
Mariam Quinones: Bioinformatics and Computational Bioscience Branch, National Institute of Allergy and Infectious Diseases
Jason M. Brenchley: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases
Heidi H. Kong: Dermatology Branch, National Cancer Institute
Roxanne Tussiwand: Howard Hughes Medical Institute, Washington University School of Medicine
Kenneth M. Murphy: Howard Hughes Medical Institute, Washington University School of Medicine
Miriam Merad: Tisch Cancer Institute and Immunology Institute, Icahn School of Medicine at Mount Sinai
Julia A. Segre: Translational and Functional Genomics Branch, National Human Genome Research Institute
Yasmine Belkaid: Immunity at Barrier Sites Initiative, National Institute of Allergy and Infectious Diseases

Nature, 2015, vol. 520, issue 7545, 104-108

Abstract: Defined skin commensal bacteria elicit a dermal dendritic-cell-dependent, long-lasting, commensal-specific CD8+ T-cell response that promotes protection against pathogens while preserving tissue homeostasis.

Date: 2015
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DOI: 10.1038/nature14052

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