Recognition determinants of broadly neutralizing human antibodies against dengue viruses

Alexander Rouvinski, Pablo Guardado-Calvo, Giovanna Barba-Spaeth, Stéphane Duquerroy, Marie-Christine Vaney, Carlos M. Kikuti, M. Erika Navarro Sanchez, Wanwisa Dejnirattisai, Wiyada Wongwiwat, Ahmed Haouz, Christine Girard-Blanc, Stéphane Petres, William E. Shepard, Philippe Desprès, Fernando Arenzana-Seisdedos, Philippe Dussart, Juthathip Mongkolsapaya (), Gavin R. Screaton () and Félix A. Rey ()
Additional contact information
Alexander Rouvinski: Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
Pablo Guardado-Calvo: Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
Giovanna Barba-Spaeth: Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
Stéphane Duquerroy: Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
Marie-Christine Vaney: Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
Carlos M. Kikuti: Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
M. Erika Navarro Sanchez: Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
Wanwisa Dejnirattisai: Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK
Wiyada Wongwiwat: Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK
Ahmed Haouz: Institut Pasteur, Protéopôle, CNRS UMR 3528, 75724 Paris Cedex 15, France
Christine Girard-Blanc: Institut Pasteur, Protéopôle, CNRS UMR 3528, 75724 Paris Cedex 15, France
Stéphane Petres: Institut Pasteur, Protéopôle, CNRS UMR 3528, 75724 Paris Cedex 15, France
William E. Shepard: Synchrotron SOLEIL, L’Orme des Merisiers, Saint Aubin, BP48, 91192 Gif-sur-Yvette, France
Philippe Desprès: Institut Pasteur, Unité des Interactions Moléculaires Flavivirus-Hôtes, 75724 Paris Cedex 15, France
Fernando Arenzana-Seisdedos: Institut Pasteur, Unité de Pathogénie Virale, INSERM U1108, 75724 Paris Cedex 15, France
Philippe Dussart: Institut Pasteur de Guyane, BP 6010, 97306 Cayenne, French Guiana
Juthathip Mongkolsapaya: Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK
Gavin R. Screaton: Hammersmith Hospital Campus, Imperial College London, London W12 0NN, UK
Félix A. Rey: Institut Pasteur, Unité de Virologie Structurale, 75724 Paris Cedex 15, France

Nature, 2015, vol. 520, issue 7545, 109-113

Abstract: Human antibodies in complex with the soluble dimeric form of the dengue virus envelope protein E recognize a quaternary epitope and exhibit strong neutralizing activity against all four virus serotypes.

Date: 2015
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DOI: 10.1038/nature14130

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