The Paf1 complex represses small-RNA-mediated epigenetic gene silencing

Katarzyna Maria Kowalik, Yukiko Shimada, Valentin Flury, Michael Beda Stadler, Julia Batki and Marc Bühler ()
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Katarzyna Maria Kowalik: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Yukiko Shimada: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Valentin Flury: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Michael Beda Stadler: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
Julia Batki: Eötvös Loránd University, Faculty of Sciences, Institute of Chemistry, 1/A Pázmány Péter sétány, Budapest 1117, Hungary
Marc Bühler: Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland

Nature, 2015, vol. 520, issue 7546, 248-252

Abstract: The fission yeast is shown to have a mechanism to prevent small RNAs from inducing heterochromatin and epigenetic gene silencing; this protective model involves the highly conserved Paf1 complex, which is known to promote transcription and processing of pre-mRNA, and protects protein-coding genes from unwanted silencing by spurious transcripts.

Date: 2015
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DOI: 10.1038/nature14337

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