Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation

J. Marsolier, M. Perichon, J. D. DeBarry, B. O. Villoutreix, J. Chluba, T. Lopez, C. Garrido, X. Z. Zhou, K. P. Lu, L. Fritsch, S. Ait-Si-Ali, M. Mhadhbi, S. Medjkane and J. B. Weitzman ()
Additional contact information
J. Marsolier: Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France
M. Perichon: Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France
J. D. DeBarry: Center for Tropical and Emerging Global Diseases, University of Georgia
B. O. Villoutreix: Université Paris Diderot, Sorbonne Paris Cité, Molécules Thérapeutiques in silico, INSERM UMR-S 973, 75013 Paris, France
J. Chluba: INSERM, UMR 866, Equipe labellisée Ligue contre le Cancer and Laboratoire d’Excellence LipSTIC, 21000 Dijon, France
T. Lopez: INSERM, UMR 866, Equipe labellisée Ligue contre le Cancer and Laboratoire d’Excellence LipSTIC, 21000 Dijon, France
C. Garrido: INSERM, UMR 866, Equipe labellisée Ligue contre le Cancer and Laboratoire d’Excellence LipSTIC, 21000 Dijon, France
X. Z. Zhou: Beth Israel Deaconess Medical Center, Harvard Medical School
K. P. Lu: Beth Israel Deaconess Medical Center, Harvard Medical School
L. Fritsch: Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France
S. Ait-Si-Ali: Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France
M. Mhadhbi: Laboratoire de Parasitologie, Ecole Nationale de Médecine Vétérinaire, Université de la Manouba, 2020 Sidi Thabet, Tunisia
S. Medjkane: Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France
J. B. Weitzman: Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, UMR 7216 CNRS, 75013 Paris, France

Nature, 2015, vol. 520, issue 7547, 378-382

Abstract: Parasites of the Theileria genus infect cattle and transform their host cells, a transformation that can be reversed by treatment with the drug buparvaquone; here, a Theileria homologue of the peptidyl-prolyl isomerase PIN1 is shown to be secreted into the host cell, where it promotes transformation and can be directly inhibited by buparvaquone.

Date: 2015
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DOI: 10.1038/nature14044

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