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β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis

Nicole M. Gaudelli, Darcie H. Long and Craig A. Townsend ()
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Nicole M. Gaudelli: Johns Hopkins University
Darcie H. Long: Johns Hopkins University
Craig A. Townsend: Johns Hopkins University

Nature, 2015, vol. 520, issue 7547, 383-387

Abstract: The monocyclic β-lactam rings of the nocardicin family of antibiotics are biosynthesized by an unprecedented activity of non-ribosomal peptide synthetases, a mechanism that is distinct from the pathways to the other classes of β-lactam antibiotics.

Date: 2015
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DOI: 10.1038/nature14100

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