Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Christina Twyman-Saint Victor, Andrew J. Rech, Amit Maity, Ramesh Rengan, Kristen E. Pauken, Erietta Stelekati, Joseph L. Benci, Bihui Xu, Hannah Dada, Pamela M. Odorizzi, Ramin S. Herati, Kathleen D. Mansfield, Dana Patsch, Ravi K. Amaravadi, Lynn M. Schuchter, Hemant Ishwaran, Rosemarie Mick, Daniel A. Pryma, Xiaowei Xu, Michael D. Feldman, Tara C. Gangadhar, Stephen M. Hahn, E. John Wherry, Robert H. Vonderheide and Andy J. Minn ()
Additional contact information
Christina Twyman-Saint Victor: Perelman School of Medicine, University of Pennsylvania
Andrew J. Rech: Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
Amit Maity: Perelman School of Medicine, University of Pennsylvania
Ramesh Rengan: Perelman School of Medicine, University of Pennsylvania
Kristen E. Pauken: Perelman School of Medicine, University of Pennsylvania
Erietta Stelekati: Perelman School of Medicine, University of Pennsylvania
Joseph L. Benci: Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
Bihui Xu: Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
Hannah Dada: Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania
Pamela M. Odorizzi: Perelman School of Medicine, University of Pennsylvania
Ramin S. Herati: Perelman School of Medicine, University of Pennsylvania
Kathleen D. Mansfield: Perelman School of Medicine, University of Pennsylvania
Dana Patsch: Perelman School of Medicine, University of Pennsylvania
Ravi K. Amaravadi: Perelman School of Medicine, University of Pennsylvania
Lynn M. Schuchter: Perelman School of Medicine, University of Pennsylvania
Hemant Ishwaran: University of Miami
Rosemarie Mick: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Daniel A. Pryma: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Xiaowei Xu: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Michael D. Feldman: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Tara C. Gangadhar: Perelman School of Medicine, University of Pennsylvania
Stephen M. Hahn: Perelman School of Medicine, University of Pennsylvania
E. John Wherry: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Robert H. Vonderheide: Perelman School of Medicine, University of Pennsylvania
Andy J. Minn: Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania

Nature, 2015, vol. 520, issue 7547, 373-377

Abstract: In this study, involving melanoma patients and a mouse model for melanoma, an optimal anti-tumour response was induced by using a combination of radiation with anti-CTLA4 and anti-PD-L1 antibody therapies, each attacking the tumour from a different angle.

Date: 2015
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DOI: 10.1038/nature14292

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