Therapy-induced tumour secretomes promote resistance and tumour progression

Anna C. Obenauf, Yilong Zou, Andrew L. Ji, Sakari Vanharanta, Weiping Shu, Hubing Shi, Xiangju Kong, Marcus C. Bosenberg, Thomas Wiesner, Neal Rosen, Roger S. Lo and Joan Massagué ()
Additional contact information
Anna C. Obenauf: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Yilong Zou: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Andrew L. Ji: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Sakari Vanharanta: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Weiping Shu: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center
Hubing Shi: University of California
Xiangju Kong: University of California
Marcus C. Bosenberg: Yale University School of Medicine
Thomas Wiesner: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
Neal Rosen: Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center
Roger S. Lo: University of California
Joan Massagué: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center

Nature, 2015, vol. 520, issue 7547, 368-372

Abstract: Tumour cells respond to an effective, targeted drug treatment with BRAF, ALK or EGFR kinase inhibitors by inducing a complex network of secreted signals that promote tumour growth, dissemination and metastasis of drug-resistant cancer cell clones, and increase the survival of drug-sensitive tumour cells, potentially contributing to incomplete tumour regression.

Date: 2015
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DOI: 10.1038/nature14336

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