Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

Tetsu Tsubogo, Hidekazu Oyamada and Shū Kobayashi ()
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Tetsu Tsubogo: School of Science, The University of Tokyo
Hidekazu Oyamada: School of Science, The University of Tokyo
Shū Kobayashi: School of Science, The University of Tokyo

Nature, 2015, vol. 520, issue 7547, 329-332

Abstract: The continuous-flow synthesis of both enantiomers of a complex molecule, the anti-inflammatory drug rolipram, is described, using only columns packed with achiral and chiral heterogeneous catalysts, thus enabling batch processing to be avoided.

Date: 2015
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DOI: 10.1038/nature14343

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