The evolutionary history of lethal metastatic prostate cancer

Gunes Gundem, Peter Van Loo, Barbara Kremeyer, Ludmil B. Alexandrov, Jose M. C. Tubio, Elli Papaemmanuil, Daniel S. Brewer, Heini M. L. Kallio, Gunilla Högnäs, Matti Annala, Kati Kivinummi, Victoria Goody, Calli Latimer, Sarah O'Meara, Kevin J. Dawson, William Isaacs, Michael R. Emmert-Buck, Matti Nykter, Christopher Foster, Zsofia Kote-Jarai, Douglas Easton, Hayley C. Whitaker, David E. Neal, Colin S. Cooper, Rosalind A. Eeles, Tapio Visakorpi, Peter J. Campbell, Ultan McDermott (), David C. Wedge () and G. Steven Bova ()
Additional contact information
Gunes Gundem: Cancer Genome Project, Wellcome Trust Sanger Institute
Peter Van Loo: Cancer Genome Project, Wellcome Trust Sanger Institute
Barbara Kremeyer: Cancer Genome Project, Wellcome Trust Sanger Institute
Ludmil B. Alexandrov: Cancer Genome Project, Wellcome Trust Sanger Institute
Jose M. C. Tubio: Cancer Genome Project, Wellcome Trust Sanger Institute
Elli Papaemmanuil: Cancer Genome Project, Wellcome Trust Sanger Institute
Daniel S. Brewer: University of East Anglia
Heini M. L. Kallio: Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital
Gunilla Högnäs: Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital
Matti Annala: Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital
Kati Kivinummi: Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital
Victoria Goody: Cancer Genome Project, Wellcome Trust Sanger Institute
Calli Latimer: Cancer Genome Project, Wellcome Trust Sanger Institute
Sarah O'Meara: Cancer Genome Project, Wellcome Trust Sanger Institute
Kevin J. Dawson: Cancer Genome Project, Wellcome Trust Sanger Institute
William Isaacs: The James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine
Michael R. Emmert-Buck: Laboratory of Pathology, National Cancer Institute, National Institutes of Health
Matti Nykter: Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital
Christopher Foster: University of Liverpool and HCA Pathology Laboratories
Zsofia Kote-Jarai: The Institute Of Cancer Research
Douglas Easton: Centre for Cancer Genetic Epidemiology, University of Cambridge
Hayley C. Whitaker: Uro-oncology Research Group, Cancer Research UK Cambridge Institute
David E. Neal: Uro-oncology Research Group, Cancer Research UK Cambridge Institute
Colin S. Cooper: University of East Anglia
Rosalind A. Eeles: The Institute Of Cancer Research
Tapio Visakorpi: Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital
Peter J. Campbell: Cancer Genome Project, Wellcome Trust Sanger Institute
Ultan McDermott: Cancer Genome Project, Wellcome Trust Sanger Institute
David C. Wedge: Cancer Genome Project, Wellcome Trust Sanger Institute
G. Steven Bova: Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital

Nature, 2015, vol. 520, issue 7547, 353-357

Abstract: The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees behind the development and spread of these cancers; an important observation was that metastases could be re-seeded multiple times, and spread from one tumour to another was frequently seen.

Date: 2015
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DOI: 10.1038/nature14347

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