SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Dohoon Kim, Brian P. Fiske, Kivanc Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard L. Possemato, Yakov Chudnovsky, Michael E. Pacold, Walter W. Chen, Jason R. Cantor, Laura M. Shelton, Dan Y. Gui, Manjae Kwon, Shakti H. Ramkissoon, Keith L. Ligon, Seong Woo Kang, Matija Snuderl, Matthew G. Vander Heiden and David M. Sabatini ()
Additional contact information
Dohoon Kim: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Brian P. Fiske: The David H. Koch Institute for Integrative Cancer Research at MIT
Kivanc Birsoy: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Elizaveta Freinkman: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Kenjiro Kami: Human Metabolome Technologies, Inc.
Richard L. Possemato: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Yakov Chudnovsky: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Michael E. Pacold: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Walter W. Chen: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Jason R. Cantor: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Laura M. Shelton: Human Metabolome Technologies America, Inc.
Dan Y. Gui: The David H. Koch Institute for Integrative Cancer Research at MIT
Manjae Kwon: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Shakti H. Ramkissoon: Dana-Farber Cancer Institute
Keith L. Ligon: Dana-Farber Cancer Institute
Seong Woo Kang: Whitehead Institute for Biomedical Research, Nine Cambridge Center
Matija Snuderl: NYU Langone Medical Center and Medical School
Matthew G. Vander Heiden: The David H. Koch Institute for Integrative Cancer Research at MIT
David M. Sabatini: Whitehead Institute for Biomedical Research, Nine Cambridge Center

Nature, 2015, vol. 520, issue 7547, 363-367

Abstract: Tumours are a low-oxygen environment, in this study glioblastoma cells are found to overexpress the serine hydroxymethyltransferase SHMT2; SHMT acts to reduce oxygen consumption, which confers the tumour cells with a survival advantage.

Date: 2015
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DOI: 10.1038/nature14363

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