A resource for cell line authentication, annotation and quality control

Mamie Yu, Suresh K. Selvaraj, May M. Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker and Richard M. Neve ()
Additional contact information
Mamie Yu: Genentech Inc.
Suresh K. Selvaraj: Genentech Inc.
May M. Y. Liang-Chu: Genentech Inc.
Sahar Aghajani: Genentech Inc.
Matthew Busse: Genentech Inc.
Jean Yuan: Genentech Inc.
Genee Lee: Genentech Inc.
Franklin Peale: Genentech Inc.
Christiaan Klijn: Genentech Inc.
Richard Bourgon: Genentech Inc.
Joshua S. Kaminker: Genentech Inc.
Richard M. Neve: Genentech Inc.

Nature, 2015, vol. 520, issue 7547, 307-311

Abstract: Abstract Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will enable our community to eradicate the use of misidentified lines and generate credible cell-based data.

Date: 2015
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DOI: 10.1038/nature14397

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