Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Dagmar Walter, Amelie Lier, Anja Geiselhart, Frederic B. Thalheimer, Sina Huntscha, Mirko C. Sobotta, Bettina Moehrle, David Brocks, Irem Bayindir, Paul Kaschutnig, Katja Muedder, Corinna Klein, Anna Jauch, Timm Schroeder, Hartmut Geiger, Tobias P. Dick, Tim Holland-Letz, Peter Schmezer, Steven W. Lane, Michael A. Rieger, Marieke A. G. Essers, David A. Williams, Andreas Trumpp and Michael D. Milsom ()
Additional contact information
Dagmar Walter: Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany
Amelie Lier: Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany
Anja Geiselhart: Deutsches Krebsforschungszentrum (DKFZ), Experimental Hematology Group, 69120 Heidelberg, Germany
Frederic B. Thalheimer: Goethe University Frankfurt, 60595 Frankfurt am Main, Germany
Sina Huntscha: Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany
Mirko C. Sobotta: Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany
Bettina Moehrle: Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, 89081 Ulm, Germany
David Brocks: Deutsches Krebsforschungszentrum (DKFZ), Experimental Hematology Group, 69120 Heidelberg, Germany
Irem Bayindir: Deutsches Krebsforschungszentrum (DKFZ), Experimental Hematology Group, 69120 Heidelberg, Germany
Paul Kaschutnig: Deutsches Krebsforschungszentrum (DKFZ), Experimental Hematology Group, 69120 Heidelberg, Germany
Katja Muedder: Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany
Corinna Klein: Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany
Anna Jauch: Institute of Human Genetics, University of Heidelberg, 69120 Heidelberg, Germany
Timm Schroeder: ETH Zurich, 4058 Basel, Switzerland
Hartmut Geiger: Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, 89081 Ulm, Germany
Tobias P. Dick: Deutsches Krebsforschungszentrum (DKFZ), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany
Tim Holland-Letz: Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany
Peter Schmezer: Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany
Steven W. Lane: QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane 4006, Australia
Michael A. Rieger: Goethe University Frankfurt, 60595 Frankfurt am Main, Germany
Marieke A. G. Essers: Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany
David A. Williams: Boston Children’s Hospital
Andreas Trumpp: Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany
Michael D. Milsom: Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany

Nature, 2015, vol. 520, issue 7548, 549-552

Abstract: Here, DNA damage is shown to occur as a direct consequence of inducing haematopoietic stem cells to exit quiescence in response to conditions of stress; in mice with mutations modelling those seen in Fanconi anaemia, this leads to a complete collapse of the haematopoietic system.

Date: 2015
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DOI: 10.1038/nature14131

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