Super-enhancers delineate disease-associated regulatory nodes in T cells

Golnaz Vahedi (), Yuka Kanno, Yasuko Furumoto, Kan Jiang, Stephen C. J. Parker, Michael R. Erdos, Sean R. Davis, Rahul Roychoudhuri, Nicholas P. Restifo, Massimo Gadina, Zhonghui Tang, Yijun Ruan, Francis S. Collins, Vittorio Sartorelli and John J. O’Shea ()
Additional contact information
Golnaz Vahedi: Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH)
Yuka Kanno: Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH)
Yasuko Furumoto: Translational Immunology Section, NIAMS, NIH, Bethesda, Maryland 20892, USA
Kan Jiang: Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH)
Stephen C. J. Parker: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
Michael R. Erdos: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
Sean R. Davis: Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Rahul Roychoudhuri: Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Nicholas P. Restifo: Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
Massimo Gadina: Translational Immunology Section, NIAMS, NIH, Bethesda, Maryland 20892, USA
Zhonghui Tang: University of Connecticut
Yijun Ruan: University of Connecticut
Francis S. Collins: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
Vittorio Sartorelli: Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, NIH, Bethesda, Maryland 20892, USA
John J. O’Shea: Lymphocyte Cell Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH)

Nature, 2015, vol. 520, issue 7548, 558-562

Abstract: A study of the super-enhancer landscape in three mouse T-helper lymphocyte subsets identifies nodes that have key roles in cell identity, with the locus encoding Bach2, a key negative regulator of effector differentiation, emerging as the most prominent T-cell super-enhancer.

Date: 2015
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DOI: 10.1038/nature14154

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