Mitochondrial DNA stress primes the antiviral innate immune response

A. Phillip West, William Khoury-Hanold, Matthew Staron, Michal C. Tal, Cristiana M. Pineda, Sabine M. Lang, Megan Bestwick, Brett A. Duguay, Nuno Raimundo, Donna A. MacDuff, Susan M. Kaech, James R. Smiley, Robert E. Means, Akiko Iwasaki and Gerald S. Shadel ()
Additional contact information
A. Phillip West: Yale School of Medicine
William Khoury-Hanold: Yale School of Medicine
Matthew Staron: Yale School of Medicine
Michal C. Tal: Yale School of Medicine
Cristiana M. Pineda: Yale School of Medicine
Sabine M. Lang: Yale School of Medicine
Megan Bestwick: Yale School of Medicine
Brett A. Duguay: Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
Nuno Raimundo: Yale School of Medicine
Donna A. MacDuff: Washington University School of Medicine
Susan M. Kaech: Yale School of Medicine
James R. Smiley: Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
Robert E. Means: Yale School of Medicine
Akiko Iwasaki: Yale School of Medicine
Gerald S. Shadel: Yale School of Medicine

Nature, 2015, vol. 520, issue 7548, 553-557

Abstract: Mitochondrial DNA stress potentiates type I interferon responses via activation of the cGAS–STING–IRF3 pathway.

Date: 2015
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DOI: 10.1038/nature14156

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