An epigenome-wide association study of total serum immunoglobulin E concentration

Liming Liang, Saffron A. G. Willis-Owen, Catherine Laprise, Kenny C. C. Wong, Gwyneth A. Davies, Thomas J. Hudson, Aristea Binia, Julian M. Hopkin, Ivana V. Yang, Elin Grundberg, Stephan Busche, Marie Hudson, Lars Rönnblom, Tomi M. Pastinen, David A. Schwartz, G. Mark Lathrop, Miriam F. Moffatt and William O. C. M. Cookson ()
Additional contact information
Liming Liang: Harvard School of Public Health
Saffron A. G. Willis-Owen: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Catherine Laprise: Université du Québec à Chicoutimi, Saguenay, Québec G7H 2B1, Canada
Kenny C. C. Wong: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Gwyneth A. Davies: Institute of Life Science, College of Medicine, Swansea University, Swansea SA2 8PP, UK
Thomas J. Hudson: Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
Aristea Binia: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Julian M. Hopkin: Institute of Life Science, College of Medicine, Swansea University, Swansea SA2 8PP, UK
Ivana V. Yang: University of Colorado School of Medicine and National Jewish Health
Elin Grundberg: McGill University and Génome Québec Innovation Centre, Montréal H3A 1B1, Canada
Stephan Busche: McGill University and Génome Québec Innovation Centre, Montréal H3A 1B1, Canada
Marie Hudson: Jewish General Hospital and Lady Davis Research Institute, Montréal H3T 1E2, Canada
Lars Rönnblom: SciLifeLab, Uppsala University, Uppsala SE-751 44, Sweden
Tomi M. Pastinen: McGill University and Génome Québec Innovation Centre, Montréal H3A 1B1, Canada
David A. Schwartz: University of Colorado School of Medicine and National Jewish Health
G. Mark Lathrop: McGill University and Génome Québec Innovation Centre, Montréal H3A 1B1, Canada
Miriam F. Moffatt: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
William O. C. M. Cookson: National Heart and Lung Institute, Imperial College, London SW3 6LY, UK

Nature, 2015, vol. 520, issue 7549, 670-674

Abstract: A survey of epigenetic associations between serum immunoglobulin E concentrations indicating allergy and methylation at CpG islands in families and a population sample has revealed associations at 36 loci that harbour genes encoding proteins including eosinophil products and phospholipid inflammatory mediators.

Date: 2015
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DOI: 10.1038/nature14125

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