A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

Alassane Mbengue, Souvik Bhattacharjee, Trupti Pandharkar, Haining Liu, Guillermina Estiu, Robert V. Stahelin, Shahir S. Rizk, Dieudonne L. Njimoh, Yana Ryan, Kesinee Chotivanich, Chea Nguon, Mehdi Ghorbal, Jose-Juan Lopez-Rubio, Michael Pfrender, Scott Emrich, Narla Mohandas, Arjen M. Dondorp, Olaf Wiest and Kasturi Haldar ()
Additional contact information
Alassane Mbengue: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Souvik Bhattacharjee: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Trupti Pandharkar: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Haining Liu: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Guillermina Estiu: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Robert V. Stahelin: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Shahir S. Rizk: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Dieudonne L. Njimoh: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Yana Ryan: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Kesinee Chotivanich: Faculty of Tropical Medicine, Mahidol University
Chea Nguon: National Center for Parasitology, Entomology and Malaria Control
Mehdi Ghorbal: CNRS 5290/IRD 224/University Montpellier 1&2 (“MiVEGEC”)
Jose-Juan Lopez-Rubio: CNRS 5290/IRD 224/University Montpellier 1&2 (“MiVEGEC”)
Michael Pfrender: University of Notre Dame
Scott Emrich: University of Notre Dame
Narla Mohandas: New York Blood Center
Arjen M. Dondorp: Faculty of Tropical Medicine, Mahidol University
Olaf Wiest: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame
Kasturi Haldar: Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame

Nature, 2015, vol. 520, issue 7549, 683-687

Abstract: Artemisinins are key anti-malarial drugs, but artemisinin resistance has been increasing; this study identifies the molecular target of artemisinins as phosphatidylinositol-3-kinase and increase of the lipid product phosphatidylinositol-3-phosphate induces resistance in Plasmodium falciparum.

Date: 2015
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DOI: 10.1038/nature14412

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