Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

Clara Moon, Megan T. Baldridge, Meghan A. Wallace, Carey-Ann D. Burnham, Herbert W. Virgin () and Thaddeus S. Stappenbeck ()
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Clara Moon: Washington University School of Medicine
Megan T. Baldridge: Washington University School of Medicine
Meghan A. Wallace: Washington University School of Medicine
Carey-Ann D. Burnham: Washington University School of Medicine
Herbert W. Virgin: Washington University School of Medicine
Thaddeus S. Stappenbeck: Washington University School of Medicine

Nature, 2015, vol. 521, issue 7550, 90-93

Abstract: Microbially driven dichotomous faecal immunoglobulin-A levels in wild-type mice within the same facility mimic the effects of chromosomal mutations, indicating that phenotypic comparisons between mice must take into account the non-chromosomal hereditary variation between different breeders.

Date: 2015
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DOI: 10.1038/nature14139

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