X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

Kristina Haslinger, Madeleine Peschke, Clara Brieke, Egle Maximowitsch and Max J. Cryle ()
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Kristina Haslinger: Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Madeleine Peschke: Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Clara Brieke: Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Egle Maximowitsch: Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Max J. Cryle: Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany

Nature, 2015, vol. 521, issue 7550, 105-109

Abstract: Glycopeptide antibiotics are biosynthesized by non-ribosomal peptide synthetases, which contain a previously uncharacterized ‘X-domain’ now shown to recruit three cytochrome P450 oxygenases that are necessary for the antibiotics to achieve their final, active conformation.

Date: 2015
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DOI: 10.1038/nature14141

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