Differential DNA mismatch repair underlies mutation rate variation across the human genome

Fran Supek and Ben Lehner ()
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Fran Supek: EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain
Ben Lehner: EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain

Nature, 2015, vol. 521, issue 7550, 81-84

Abstract: An analysis of how regional mutation rates vary across 652 tumours identifies variable DNA mismatch repair as the basis of the characteristic regional variation in mutation rates seen across the human genome; the results show that differential DNA repair, rather than differential mutation supply, is likely to be the primary cause of this variation.

Date: 2015
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DOI: 10.1038/nature14173

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