A direct GABAergic output from the basal ganglia to frontal cortex

Arpiar Saunders, Ian A. Oldenburg, Vladimir K. Berezovskii, Caroline A. Johnson, Nathan D. Kingery, Hunter L. Elliott, Tiao Xie, Charles R. Gerfen and Bernardo L. Sabatini ()
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Arpiar Saunders: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Ian A. Oldenburg: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Vladimir K. Berezovskii: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Caroline A. Johnson: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Nathan D. Kingery: Neurobiology Imaging Facility, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Hunter L. Elliott: Image and Data Analysis Core, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Tiao Xie: Image and Data Analysis Core, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
Charles R. Gerfen: Laboratory of Systems Neuroscience, National Institute of Mental Health
Bernardo L. Sabatini: Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA

Nature, 2015, vol. 521, issue 7550, 85-89

Abstract: Anatomical and functional analyses reveal the existence of two types of globus pallidus externus neurons that directly control cortex, suggesting a pathway by which dopaminergic drugs used to treat neuropsychiatric disorders may act in the basal ganglia to modulate cortex.

Date: 2015
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DOI: 10.1038/nature14179

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