Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

Shabnam Shalapour, Joan Font-Burgada, Giuseppe Di Caro, Zhenyu Zhong, Elsa Sanchez-Lopez, Debanjan Dhar, Gerald Willimsky, Massimo Ammirante, Amy Strasner, Donna E. Hansel, Christina Jamieson, Christopher J. Kane, Tobias Klatte, Peter Birner, Lukas Kenner and Michael Karin ()
Additional contact information
Shabnam Shalapour: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Joan Font-Burgada: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Giuseppe Di Caro: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Zhenyu Zhong: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Elsa Sanchez-Lopez: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Debanjan Dhar: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Gerald Willimsky: Institute of Immunology, Charité Campus Buch
Massimo Ammirante: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Amy Strasner: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)
Donna E. Hansel: School of Medicine, University of California San Diego
Christina Jamieson: University of California San Diego
Christopher J. Kane: University of California San Diego
Tobias Klatte: Medical University of Vienna
Peter Birner: Medical University of Vienna
Lukas Kenner: Medical University of Vienna
Michael Karin: Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California San Diego (UCSD)

Nature, 2015, vol. 521, issue 7550, 94-98

Abstract: IgA plasmocytes are shown to promote resistance to the immunogenic chemotherapeutic oxaliplatin in prostate cancer mouse models by inhibiting activation of cytotoxic T cells; immunosuppressive plasma cells, which are also found in human-therapy-resistant prostate cancer, are generated in response to TGFβ, and their functionality depends on PD-L1 expression and IL-10 secretion.

Date: 2015
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DOI: 10.1038/nature14395

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