Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity

Yaron Carmi (), Matthew H. Spitzer, Ian L. Linde, Bryan M. Burt, Tyler R. Prestwood, Nicola Perlman, Matthew G. Davidson, Justin A. Kenkel, Ehud Segal, Ganesh V. Pusapati, Nupur Bhattacharya and Edgar G. Engleman ()
Additional contact information
Yaron Carmi: School of Medicine, Stanford University
Matthew H. Spitzer: School of Medicine, Stanford University
Ian L. Linde: School of Medicine, Stanford University
Bryan M. Burt: School of Medicine, Stanford University
Tyler R. Prestwood: School of Medicine, Stanford University
Nicola Perlman: School of Medicine, Stanford University
Matthew G. Davidson: School of Medicine, Stanford University
Justin A. Kenkel: School of Medicine, Stanford University
Ehud Segal: School of Medicine, Stanford University
Ganesh V. Pusapati: School of Medicine, Stanford University
Nupur Bhattacharya: School of Medicine, Stanford University
Edgar G. Engleman: School of Medicine, Stanford University

Nature, 2015, vol. 521, issue 7550, 99-104

Abstract: Naturally occurring tumour-binding IgG antibodies are shown to initiate the rejection of allogeneic tumours, whereby Fc-receptor-mediated uptake of tumour immune complexes into dendritic cells activates tumour-reactive T cells, and intra-tumoral injection of allogeneic IgG together with dendritic cell adjuvants induces systemic T-cell-mediated antitumour responses.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature14424 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:521:y:2015:i:7550:d:10.1038_nature14424

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14424

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().