YAP is essential for tissue tension to ensure vertebrate 3D body shape

Sean Porazinski, Huijia Wang, Yoichi Asaoka, Martin Behrndt, Tatsuo Miyamoto, Hitoshi Morita, Shoji Hata, Takashi Sasaki, S. F. Gabriel Krens, Yumi Osada, Satoshi Asaka, Akihiro Momoi, Sarah Linton, Joel B. Miesfeld, Brian A. Link, Takeshi Senga, Atahualpa Castillo-Morales, Araxi O. Urrutia, Nobuyoshi Shimizu, Hideaki Nagase, Shinya Matsuura, Stefan Bagby, Hisato Kondoh, Hiroshi Nishina (), Carl-Philipp Heisenberg () and Makoto Furutani-Seiki ()
Additional contact information
Sean Porazinski: University of Bath, Bath BA2 7AY, UK
Huijia Wang: University of Bath, Bath BA2 7AY, UK
Yoichi Asaoka: Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan
Martin Behrndt: IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria
Tatsuo Miyamoto: Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan
Hitoshi Morita: IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria
Shoji Hata: Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan
Takashi Sasaki: School of Medicine, Keio University, Tokyo 160-8582, Japan
S. F. Gabriel Krens: IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria
Yumi Osada: Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan
Satoshi Asaka: Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan
Akihiro Momoi: Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan
Sarah Linton: University of Bath, Bath BA2 7AY, UK
Joel B. Miesfeld: Neurobiology, and Anatomy, Medical College of Wisconsin
Brian A. Link: Neurobiology, and Anatomy, Medical College of Wisconsin
Takeshi Senga: Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
Atahualpa Castillo-Morales: University of Bath, Bath BA2 7AY, UK
Araxi O. Urrutia: University of Bath, Bath BA2 7AY, UK
Nobuyoshi Shimizu: School of Medicine, Keio University, Tokyo 160-8582, Japan
Hideaki Nagase: Kennedy Institute of Rheumatology, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK
Shinya Matsuura: Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan
Stefan Bagby: University of Bath, Bath BA2 7AY, UK
Hisato Kondoh: Japan Science and Technology Agency (JST), ERATO-SORST Kondoh Differentiation Signaling Project, Kyoto 606-8305, Japan
Hiroshi Nishina: Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, Japan
Carl-Philipp Heisenberg: IST Austria, Am Campus 1, A-3400 Klosterneuburg, Austria
Makoto Furutani-Seiki: University of Bath, Bath BA2 7AY, UK

Nature, 2015, vol. 521, issue 7551, 217-221

Abstract: D’Arcy Thompson predicted a century ago that animal body shape is conditioned by gravity, but there has been no animal model to study how cellular forces are coordinated to generate body shapes that withstand gravity; the hirame medaka fish mutant, with pronounced body flattening, reveals how the hirame/YAP gene controls gravity-resisting cellular forces to produce complex 3D organs and body shapes.

Date: 2015
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DOI: 10.1038/nature14215

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