The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

Colleen A. McHugh, Chun-Kan Chen, Amy Chow, Christine F. Surka, Christina Tran, Patrick McDonel, Amy Pandya-Jones, Mario Blanco, Christina Burghard, Annie Moradian, Michael J. Sweredoski, Alexander A. Shishkin, Julia Su, Eric S. Lander, Sonja Hess, Kathrin Plath and Mitchell Guttman ()
Additional contact information
Colleen A. McHugh: California Institute of Technology
Chun-Kan Chen: California Institute of Technology
Amy Chow: California Institute of Technology
Christine F. Surka: California Institute of Technology
Christina Tran: California Institute of Technology
Patrick McDonel: Broad Institute of MIT and Harvard
Amy Pandya-Jones: Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles
Mario Blanco: California Institute of Technology
Christina Burghard: California Institute of Technology
Annie Moradian: Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology
Michael J. Sweredoski: Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology
Alexander A. Shishkin: California Institute of Technology
Julia Su: California Institute of Technology
Eric S. Lander: Broad Institute of MIT and Harvard
Sonja Hess: Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology
Kathrin Plath: Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles
Mitchell Guttman: California Institute of Technology

Nature, 2015, vol. 521, issue 7551, 232-236

Abstract: The mechanisms by which Xist, a long non-coding RNA, silences one X chromosome in female mammals are unknown; here a mass spectrometry-based approach is developed to identify several proteins that interact directly with Xist, including the transcriptional repressor SHARP that is required for transcriptional silencing through the histone deacetylase HDAC3.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://www.nature.com/articles/nature14443 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:521:y:2015:i:7551:d:10.1038_nature14443

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14443

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().