Selection on noise constrains variation in a eukaryotic promoter

Brian P. H. Metzger, David C. Yuan, Jonathan D. Gruber, Fabien Duveau and Patricia J. Wittkopp ()
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Brian P. H. Metzger: University of Michigan
David C. Yuan: Cellular, and Developmental Biology, University of Michigan
Jonathan D. Gruber: University of Michigan
Fabien Duveau: University of Michigan
Patricia J. Wittkopp: University of Michigan

Nature, 2015, vol. 521, issue 7552, 344-347

Abstract: Quantifying activity of cis-regulatory sequences controlling gene expression shows that selection on expression noise has a greater impact on sequence variation than selection on mean expression level.

Date: 2015
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DOI: 10.1038/nature14244

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