Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice

Rene C. Adam, Hanseul Yang, Shira Rockowitz, Samantha B. Larsen, Maria Nikolova, Daniel S. Oristian, Lisa Polak, Meelis Kadaja, Amma Asare, Deyou Zheng and Elaine Fuchs ()
Additional contact information
Rene C. Adam: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University
Hanseul Yang: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University
Shira Rockowitz: Albert Einstein College of Medicine
Samantha B. Larsen: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University
Maria Nikolova: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University
Daniel S. Oristian: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University
Lisa Polak: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University
Meelis Kadaja: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University
Amma Asare: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University
Deyou Zheng: Albert Einstein College of Medicine
Elaine Fuchs: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology & Development, The Rockefeller University

Nature, 2015, vol. 521, issue 7552, 366-370

Abstract: An analysis of mouse skin reveals that super-enhancers are critical to identity, lineage commitment and plasticity of adult stem cells; dynamic super-enhancer remodelling in new niches is dependent on the levels of pioneer transcription factor SOX9, which is identified as a key regulator of super-enhancer chromatin for hair follicle stem cells.

Date: 2015
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DOI: 10.1038/nature14289

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