Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

Emily P. Thi, Chad E. Mire, Amy C. H. Lee, Joan B. Geisbert, Joy Z. Zhou, Krystle N. Agans, Nicholas M. Snead, Daniel J. Deer, Trisha R. Barnard, Karla A. Fenton, Ian MacLachlan and Thomas W. Geisbert ()
Additional contact information
Emily P. Thi: Tekmira Pharmaceuticals
Chad E. Mire: Galveston National Laboratory, University of Texas Medical Branch
Amy C. H. Lee: Tekmira Pharmaceuticals
Joan B. Geisbert: Galveston National Laboratory, University of Texas Medical Branch
Joy Z. Zhou: Tekmira Pharmaceuticals
Krystle N. Agans: Galveston National Laboratory, University of Texas Medical Branch
Nicholas M. Snead: Tekmira Pharmaceuticals
Daniel J. Deer: Galveston National Laboratory, University of Texas Medical Branch
Trisha R. Barnard: Tekmira Pharmaceuticals
Karla A. Fenton: Galveston National Laboratory, University of Texas Medical Branch
Ian MacLachlan: Tekmira Pharmaceuticals
Thomas W. Geisbert: Galveston National Laboratory, University of Texas Medical Branch

Nature, 2015, vol. 521, issue 7552, 362-365

Abstract: Ebola-virus-targeting short interfering RNAs (siRNAs) encapsulated in lipid nanoparticles are adapted to the current outbreak strain of the virus, and the siRNA cocktail is shown to protect nonhuman primates fully when administered 3 days after challenge with the current West African Ebola virus isolate; upon viral sequence data availability, the drug can be adapted to the new virus and produced in as little as 8 weeks.

Date: 2015
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DOI: 10.1038/nature14442

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