Recursive splicing in long vertebrate genes

Christopher R. Sibley, Warren Emmett, Lorea Blazquez, Ana Faro, Nejc Haberman, Michael Briese, Daniah Trabzuni, Mina Ryten, Michael E. Weale, John Hardy, Miha Modic, Tomaž Curk, Stephen W. Wilson, Vincent Plagnol () and Jernej Ule ()
Additional contact information
Christopher R. Sibley: UCL Institute of Neurology
Warren Emmett: University College London Genetics Institute
Lorea Blazquez: UCL Institute of Neurology
Ana Faro: University College London
Nejc Haberman: UCL Institute of Neurology
Michael Briese: MRC Laboratory of Molecular Biology
Daniah Trabzuni: UCL Institute of Neurology
Mina Ryten: UCL Institute of Neurology
Michael E. Weale: King’s College London, Guy’s Hospital
John Hardy: UCL Institute of Neurology
Miha Modic: MRC Laboratory of Molecular Biology
Tomaž Curk: Faculty of Computer and Information Science, University of Ljubljana
Stephen W. Wilson: University College London
Vincent Plagnol: University College London Genetics Institute
Jernej Ule: UCL Institute of Neurology

Nature, 2015, vol. 521, issue 7552, 371-375

Abstract: Highly conserved recursive splice sites are identified in vertebrates, particularly within long genes encoding proteins that are involved in neuronal development; analysis of the splicing mechanism reveals that such recursive splicing sites can be used to dictate different mRNA isoforms.

Date: 2015
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DOI: 10.1038/nature14466

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