REV7 counteracts DNA double-strand break resection and affects PARP inhibition

Guotai Xu, J. Ross Chapman, Inger Brandsma, Jingsong Yuan, Martin Mistrik, Peter Bouwman, Jirina Bartkova, Ewa Gogola, Daniël Warmerdam, Marco Barazas, Janneke E. Jaspers, Kenji Watanabe, Mark Pieterse, Ariena Kersbergen, Wendy Sol, Patrick H. N. Celie, Philip C. Schouten, Bram van den Broek, Ahmed Salman, Marja Nieuwland, Iris de Rink, Jorma de Ronde, Kees Jalink, Simon J. Boulton, Junjie Chen, Dik C. van Gent, Jiri Bartek, Jos Jonkers, Piet Borst and Sven Rottenberg ()
Additional contact information
Guotai Xu: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
J. Ross Chapman: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Inger Brandsma: Erasmus, University Medical Center, 3000 CA Rotterdam, The Netherlands
Jingsong Yuan: University of Texas MD Anderson Cancer Center
Martin Mistrik: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic
Peter Bouwman: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Jirina Bartkova: Danish Cancer Society Research Center, 2100 Copenhagen, Denmark
Ewa Gogola: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Daniël Warmerdam: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Marco Barazas: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Janneke E. Jaspers: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Kenji Watanabe: Danish Cancer Society Research Center, 2100 Copenhagen, Denmark
Mark Pieterse: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Ariena Kersbergen: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Wendy Sol: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Patrick H. N. Celie: Protein Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Philip C. Schouten: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Bram van den Broek: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Ahmed Salman: The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK
Marja Nieuwland: Deep Sequencing Core Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Iris de Rink: Deep Sequencing Core Facility, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Jorma de Ronde: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Kees Jalink: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Simon J. Boulton: DNA Damage Response Laboratory, London Research Institute, Cancer Research UK, Clare Hall, South Mimms, Hertfordshire EN6 3LD, UK
Junjie Chen: University of Texas MD Anderson Cancer Center
Dik C. van Gent: Erasmus, University Medical Center, 3000 CA Rotterdam, The Netherlands
Jiri Bartek: Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic
Jos Jonkers: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Piet Borst: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
Sven Rottenberg: The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands

Nature, 2015, vol. 521, issue 7553, 541-544

Abstract: Loss of REV7 is shown to regulate end resection of double-stranded DNA breaks in BRCA1-deficient cells, leading to PARP inhibitor resistance and restoration of homologous recombination; REV7 dictates pathway choice in BRCA1-deficient cells and during immunoglobulin class switching.

Date: 2015
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DOI: 10.1038/nature14328

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