Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42

Seung-Yeol Park, Jia-Shu Yang, Angela B. Schmider, Roy J. Soberman and Victor W. Hsu ()
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Seung-Yeol Park: Immunology and Allergy, Brigham and Women’s Hospital
Jia-Shu Yang: Immunology and Allergy, Brigham and Women’s Hospital
Angela B. Schmider: Harvard Medical School
Roy J. Soberman: Harvard Medical School
Victor W. Hsu: Immunology and Allergy, Brigham and Women’s Hospital

Nature, 2015, vol. 521, issue 7553, 529-532

Abstract: The COPI complex, which has a role in retrograde transport through the Golgi, is shown to also mediate anterograde tubular transport through the Golgi; in response to external stimuli, the small GTPase CDC42 acts as an essential modulator of bidirectional Golgi transport, and promotes the sorting of cargoes destined for anterograde transport into the tubules at the expense of those targeted for retrograde transport.

Date: 2015
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DOI: 10.1038/nature14457

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