eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

Amy S. Y. Lee, Philip J. Kranzusch and Jamie H. D. Cate ()
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Amy S. Y. Lee: University of California, Berkeley, Berkeley, California 94720, USA
Philip J. Kranzusch: University of California, Berkeley, Berkeley, California 94720, USA
Jamie H. D. Cate: University of California, Berkeley, Berkeley, California 94720, USA

Nature, 2015, vol. 522, issue 7554, 111-114

Abstract: Eukaryotic initiation factor 3 (eIF3)—the deregulation of which has been linked with diverse cancers—is shown to bind to and direct the specialized translation of a subset of messenger RNAs, primarily involved in cell proliferation, differentiation and apoptosis, and can exert either translational activation or repression.

Date: 2015
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DOI: 10.1038/nature14267

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