Niche-induced cell death and epithelial phagocytosis regulate hair follicle stem cell pool

Kailin R. Mesa, Panteleimon Rompolas, Giovanni Zito, Peggy Myung, Thomas Y. Sun, Samara Brown, David G. Gonzalez, Krastan B. Blagoev, Ann M. Haberman and Valentina Greco ()
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Kailin R. Mesa: Yale School of Medicine
Panteleimon Rompolas: Yale School of Medicine
Giovanni Zito: University of Palermo
Peggy Myung: Yale School of Medicine
Thomas Y. Sun: Yale School of Medicine
Samara Brown: Yale School of Medicine
David G. Gonzalez: Yale School of Medicine
Krastan B. Blagoev: National Science Foundation
Ann M. Haberman: Yale School of Medicine
Valentina Greco: Yale School of Medicine

Nature, 2015, vol. 522, issue 7554, 94-97

Abstract: Mouse hair follicles in the skin cycle between growth and regression, while maintaining a pool of stem cells for continued regeneration; here, live imaging is used to show that a combination of niche-induced stem cell apoptosis and epithelial phagocytosis underlies regression, regulating the stem cell pool.

Date: 2015
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DOI: 10.1038/nature14306

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