Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

Harrison W. Gabel, Benyam Kinde, Hume Stroud, Caitlin S. Gilbert, David A. Harmin, Nathaniel R. Kastan, Martin Hemberg, Daniel H. Ebert and Michael E. Greenberg ()
Additional contact information
Harrison W. Gabel: Harvard Medical School
Benyam Kinde: Harvard Medical School
Hume Stroud: Harvard Medical School
Caitlin S. Gilbert: Harvard Medical School
David A. Harmin: Harvard Medical School
Nathaniel R. Kastan: Harvard Medical School
Martin Hemberg: Children’s Hospital Boston, Center for Brain Science and Swartz Center for Theoretical Neuroscience, Harvard University, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Daniel H. Ebert: Harvard Medical School
Michael E. Greenberg: Harvard Medical School

Nature, 2015, vol. 522, issue 7554, 89-93

Abstract: Rett syndrome is caused by mutation of the MECP2 gene that codes for a protein that binds methylated DNA; this study reveals that MeCP2 affects the expression of long genes, which often serve neuronal functions.

Date: 2015
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DOI: 10.1038/nature14319

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