Cardiac lymphatics are heterogeneous in origin and respond to injury

Linda Klotz, Sophie Norman, Joaquim Miguel Vieira, Megan Masters, Mala Rohling, Karina N. Dubé, Sveva Bollini, Fumio Matsuzaki, Carolyn A. Carr and Paul R. Riley ()
Additional contact information
Linda Klotz: University College London, Institute of Child Health, Molecular Medicine Unit
Sophie Norman: University of Oxford, Anatomy and Genetics
Joaquim Miguel Vieira: University of Oxford, Anatomy and Genetics
Megan Masters: University of Oxford, Anatomy and Genetics
Mala Rohling: University of Oxford, Anatomy and Genetics
Karina N. Dubé: University College London, Institute of Child Health, Molecular Medicine Unit
Sveva Bollini: Regenerative Medicine Laboratory, University of Genoa & IRCCS AOU San Martino-IST
Fumio Matsuzaki: Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology
Carolyn A. Carr: University of Oxford, Anatomy and Genetics
Paul R. Riley: University of Oxford, Anatomy and Genetics

Nature, 2015, vol. 522, issue 7554, 62-67

Abstract: Abstract The lymphatic vasculature is a blind-ended network crucial for tissue-fluid homeostasis, immune surveillance and lipid absorption from the gut. Recent evidence has proposed an entirely venous-derived mammalian lymphatic system. By contrast, here we show that cardiac lymphatic vessels in mice have a heterogeneous cellular origin, whereby formation of at least part of the cardiac lymphatic network is independent of sprouting from veins. Multiple Cre–lox-based lineage tracing revealed a potential contribution from the putative haemogenic endothelium during development, and discrete lymphatic endothelial progenitor populations were confirmed by conditional knockout of Prox1 in Tie2+ and Vav1+ compartments. In the adult heart, myocardial infarction promoted a significant lymphangiogenic response, which was augmented by treatment with VEGF-C, resulting in improved cardiac function. These data prompt the re-evaluation of a century-long debate on the origin of lymphatic vessels and suggest that lymphangiogenesis may represent a therapeutic target to promote cardiac repair following injury.

Date: 2015
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature14483 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:522:y:2015:i:7554:d:10.1038_nature14483

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14483

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().