RETRACTED ARTICLE: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

Thomas R. Cox, Robin M. H. Rumney, Erwin M. Schoof, Lara Perryman, Anette M. Høye, Ankita Agrawal, Demelza Bird, Norain Ab Latif, Hamish Forrest, Holly R. Evans, Iain D. Huggins, Georgina Lang, Rune Linding, Alison Gartland () and Janine T. Erler ()
Additional contact information
Thomas R. Cox: Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)
Robin M. H. Rumney: The Mellanby Centre for Bone Research, The University of Sheffield
Erwin M. Schoof: Cellular Signal Integration Group (C-SIG), Technical University of Denmark (DTU), Lyngby, DK-2800, Denmark
Lara Perryman: Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)
Anette M. Høye: Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)
Ankita Agrawal: The Mellanby Centre for Bone Research, The University of Sheffield
Demelza Bird: Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research
Norain Ab Latif: The Mellanby Centre for Bone Research, The University of Sheffield
Hamish Forrest: The Mellanby Centre for Bone Research, The University of Sheffield
Holly R. Evans: The Mellanby Centre for Bone Research, The University of Sheffield
Iain D. Huggins: The Mellanby Centre for Bone Research, The University of Sheffield
Georgina Lang: Hypoxia and Metastasis Team, Cancer Research UK Tumour Cell Signalling Unit, The Institute of Cancer Research
Rune Linding: Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)
Alison Gartland: The Mellanby Centre for Bone Research, The University of Sheffield
Janine T. Erler: Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH)

Nature, 2015, vol. 522, issue 7554, 106-110

Abstract: Metastasis to the bone of certain breast cancers can be driven by the enzyme lysyl oxidase (LOX) produced by primary tumour cells.

Date: 2015
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DOI: 10.1038/nature14492

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