Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

Edward J. Grow, Ryan A. Flynn, Shawn L. Chavez, Nicholas L. Bayless, Mark Wossidlo, Daniel J. Wesche, Lance Martin, Carol B. Ware, Catherine A. Blish, Howard Y. Chang, Renee A. Reijo Pera and Joanna Wysocka ()
Additional contact information
Edward J. Grow: Stanford University School of Medicine
Ryan A. Flynn: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Shawn L. Chavez: Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford University
Nicholas L. Bayless: Stanford Immunology, Stanford University School of Medicine
Mark Wossidlo: Stanford University School of Medicine
Daniel J. Wesche: Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford University
Lance Martin: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Carol B. Ware: University of Washington
Catherine A. Blish: Stanford University School of Medicine
Howard Y. Chang: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Renee A. Reijo Pera: Stanford University School of Medicine
Joanna Wysocka: Institute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford University

Nature, 2015, vol. 522, issue 7555, 221-225

Abstract: The human endogenous retrovirus HERVK is normally silenced, but here the surprising discovery is made that in early human embryo development it is expressed, producing retroviral-like particles.

Date: 2015
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DOI: 10.1038/nature14308

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