Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling

Jinhu Wang, Jingli Cao, Amy L. Dickson and Kenneth D. Poss ()
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Jinhu Wang: Duke University Medical Center
Jingli Cao: Duke University Medical Center
Amy L. Dickson: Duke University Medical Center
Kenneth D. Poss: Duke University Medical Center

Nature, 2015, vol. 522, issue 7555, 226-230

Abstract: Using a genetic approach in zebrafish, the mesothelial covering of the heart—the epicardium—is shown to have a high regenerative ability after injury, a process that is driven by Hedgehog signalling originating from the outflow tract.

Date: 2015
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DOI: 10.1038/nature14325

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