Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

Fadi J. Najm, Mayur Madhavan, Anita Zaremba, Elizabeth Shick, Robert T. Karl, Daniel C. Factor, Tyler E. Miller, Zachary S. Nevin, Christopher Kantor, Alex Sargent, Kevin L. Quick, Daniela M. Schlatzer, Hong Tang, Ruben Papoian, Kyle R. Brimacombe, Min Shen, Matthew B. Boxer, Ajit Jadhav, Andrew P. Robinson, Joseph R. Podojil, Stephen D. Miller, Robert H. Miller () and Paul J. Tesar ()
Additional contact information
Fadi J. Najm: Case Western Reserve University School of Medicine
Mayur Madhavan: Case Western Reserve University School of Medicine
Anita Zaremba: Case Western Reserve University School of Medicine
Elizabeth Shick: Case Western Reserve University School of Medicine
Robert T. Karl: Case Western Reserve University School of Medicine
Daniel C. Factor: Case Western Reserve University School of Medicine
Tyler E. Miller: Case Western Reserve University School of Medicine
Zachary S. Nevin: Case Western Reserve University School of Medicine
Christopher Kantor: Case Western Reserve University School of Medicine
Alex Sargent: Case Western Reserve University School of Medicine
Kevin L. Quick: PerkinElmer
Daniela M. Schlatzer: Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine
Hong Tang: Drug Discovery Center, University of Cincinnati College of Medicine
Ruben Papoian: Drug Discovery Center, University of Cincinnati College of Medicine
Kyle R. Brimacombe: National Center for Advancing Translational Sciences, National Institutes of Health
Min Shen: National Center for Advancing Translational Sciences, National Institutes of Health
Matthew B. Boxer: National Center for Advancing Translational Sciences, National Institutes of Health
Ajit Jadhav: National Center for Advancing Translational Sciences, National Institutes of Health
Andrew P. Robinson: Feinberg School of Medicine, Northwestern University
Joseph R. Podojil: Feinberg School of Medicine, Northwestern University
Stephen D. Miller: Feinberg School of Medicine, Northwestern University
Robert H. Miller: Case Western Reserve University School of Medicine
Paul J. Tesar: Case Western Reserve University School of Medicine

Nature, 2015, vol. 522, issue 7555, 216-220

Abstract: Two drugs, miconazole and clobetasol, have functions that modulate differentiation of oligodendrocyte progenitor cells directly, enhance remyelination, and significantly reduce disease severity in mouse models of multiple sclerosis.

Date: 2015
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DOI: 10.1038/nature14335

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