Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

Simon J. Elsässer (), Kyung-Min Noh, Nichole Diaz, C. David Allis () and Laura A. Banaszynski ()
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Simon J. Elsässer: MRC Laboratory of Molecular Biology
Kyung-Min Noh: Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University
Nichole Diaz: Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University
C. David Allis: Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University
Laura A. Banaszynski: Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University

Nature, 2015, vol. 522, issue 7555, 240-244

Abstract: Transposable elements in mammalian genomes need to be silenced to avoid detrimental genome instability; here, the histone variant H3.3 is shown to have an important role in silencing endogenous retroviral elements.

Date: 2015
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DOI: 10.1038/nature14345

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