Synthesis and applications of RNAs with position-selective labelling and mosaic composition

Yu Liu, Erik Holmstrom, Jinwei Zhang, Ping Yu, Jinbu Wang, Marzena A. Dyba, Chen De, Jinfa Ying, Stephen Lockett, David J. Nesbitt, Adrian R. Ferré-D’Amaré, Rui Sousa, Jason R. Stagno and Yun-Xing Wang ()
Additional contact information
Yu Liu: Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Erik Holmstrom: JILA, University of Colorado
Jinwei Zhang: Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute
Ping Yu: Structural Biophysics Laboratory, Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
Jinbu Wang: Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Marzena A. Dyba: Structural Biophysics Laboratory, Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
Chen De: Optical Microscopy and Analysis Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
Jinfa Ying: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
Stephen Lockett: Optical Microscopy and Analysis Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
David J. Nesbitt: JILA, University of Colorado
Adrian R. Ferré-D’Amaré: Biochemistry and Biophysics Center, National Heart, Lung and Blood Institute
Rui Sousa: University of Texas Health Science Center
Jason R. Stagno: Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Yun-Xing Wang: Protein-Nucleic Acid Interaction Section, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health

Nature, 2015, vol. 522, issue 7556, 368-372

Abstract: A hybrid solid–liquid phase transcription method and automated robotic platform synthesizes position-specific, fluorescence- or isotope-labelled RNA.

Date: 2015
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DOI: 10.1038/nature14352

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