MET is required for the recruitment of anti-tumoural neutrophils

Veronica Finisguerra, Giusy Di Conza, Mario Di Matteo, Jens Serneels, Sandra Costa, A. A. Roger Thompson, Els Wauters, Sarah Walmsley, Hans Prenen, Zvi Granot, Andrea Casazza () and Massimiliano Mazzone ()
Additional contact information
Veronica Finisguerra: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
Giusy Di Conza: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
Mario Di Matteo: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
Jens Serneels: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
Sandra Costa: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
A. A. Roger Thompson: University of Sheffield
Els Wauters: University Hospital Gasthuisberg
Sarah Walmsley: University of Sheffield
Hans Prenen: Digestive Oncology Unit, University Hospital Gasthuisberg, KU Leuven
Zvi Granot: The Institute for Medical Research Israel-Canada, The Hebrew University
Andrea Casazza: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center
Massimiliano Mazzone: Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center

Nature, 2015, vol. 522, issue 7556, 349-353

Abstract: Whether neutrophils exert an anti- or pro-tumorigenic function has remained controversial; now, expression of the receptor molecule MET in neutrophils is shown to be required for their ability to restrict tumour growth in several mouse cancer models, with potential implications for human cancer therapy.

Date: 2015
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DOI: 10.1038/nature14407

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